Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer

Recruiting now

Conditions studied: Non Small Cell Lung Cancer

In brief

The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected lung tumors. The main questions it aims to answer are: * Can a high-specificity CLE-based score accurately identify NSCLC during endoscopic procedures? * Can CLE imaging criteria improve biopsy yield and help differentiate histological subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors)? Participants will: * Undergo standard bronchoscopic navigation procedures with additional real-time imaging using CLE and biopsy * Have CLE findings compared with standard histopathological analysis of biopsy samples

Key facts

Study ID

NCT07538947

Run by

Central Hospital, Nancy, France

People needed

70

Starts

2026-04-03

Expected to finish

2026-06-15

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient for whom endobronchial navigation-guided biopsy is indicated
• Complete medical data (CLE images and histopathological results)

You may not qualify if…

• Persons referred to in Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the French Public Health Code:
• Individuals under 18 years of age
• Adult persons subject to legal protection measures (guardianship, curatorship, or judicial protection)
• Adult persons unable to express their consent
• Persons deprived of liberty by judicial or administrative decision, and persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1

Where it is running

• CHRU Nancy — Nancy, France (enrolling)

Full record on ClinicalTrials.gov

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