Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth

Starting soon · Not applicable

Conditions studied: Concentrated Growth Factor

In brief

This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices. Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth. In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period. The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.

Key facts

Study ID

NCT07538921

Run by

Cairo University

People needed

7

Starts

2026-06-01

Expected to finish

2027-07-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Donor Tooth : any 3rd molar tooth with fully developed roots (confirmed radiographically) and not functionally used (semi impacted, impacted but easily to be extracted, absence of the opposing etc…) .
• Recipient Site : Recipient 1st or 2nd molar region (either upper or lower) with adequate bone volume to receive the auto transplanted tooth.
• Oral Health: Good general oral hygiene and absence of active periodontal disease.
• Systemic Health: patients with no contraindications for minor oral surgery.

You may not qualify if…

• Poor Oral Hygiene: Presence of uncontrolled gingivitis or periodontitis.
• Systemic Conditions: Patients with systemic diseases that may impair healing (e.g., uncontrolled diabetes, immunosuppression, bleeding disorders or bone metabolic diseases ).
• Smoking: Active smokers or tobacco users.
• Pregnancy or Lactation: Female patients who are pregnant or breastfeeding

Where it is running

• Faculty of oral and dental surgery cairo university — Cairo, Elmanial, Egypt

Full record on ClinicalTrials.gov

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