Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
Recruiting now · Not applicable
Conditions studied: Postinduction Hypotension
In brief
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
Key facts
- Study ID
- NCT07538388
- Run by
- Universitätsklinikum Hamburg-Eppendorf
- People needed
- 446
- Starts
- 2026-05-07
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-06-29
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- We will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:
- Age ≥65 years
- ASA physical status III or IV
- Chronic arterial hypertension
- Diabetes mellitus requiring medication
- Intra-abdominal surgery
- Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)
You may not qualify if…
- Pregnancy
- Cardiac arrhythmia
- History of intracranial hemorrhage or intracranial aneurysm
- Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
- Patients who are unable to understand, read, and provide informed consent in German
Where it is running
- Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf — Düsseldorf, Germany (enrolling)
- Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf — Hamburg, Germany (enrolling)
- Department of Anaesthesiology, University Hospital LMU Munich — München, Germany (enrolling)
- Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin — Berlin, Germany
Full record on ClinicalTrials.gov
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