Predictors & Mechanisms of Adolescent PTSD

Starting soon · Early Phase 1

Conditions studied: Posttraumatic Stress Disorder (PTSD), Trauma Exposure

In brief

This study examines how adolescents with trauma-related symptoms respond to stress and strong emotions. The study assesses brain activity, physiological responses, and behavior during experimental tasks that involve responding to potential threats, regulating emotions, and repeatedly imagining details of a personally experienced stressful or traumatic event using a script-driven imagery task. The study evaluates whether repeated imaginal exposure is associated with changes in anxiety and physiological responses across sessions, and whether baseline patterns of threat reactivity and emotion regulation are associated with individual differences in response to the exposure task. Outcomes include self-reported anxiety, subjective distress ratings, and psychophysiological indices such as heart rate, skin conductance, and electromyographic activity. The goal of this research is to improve understanding of biobehavioral processes related to trauma exposure in adolescents and to identify potential predictors of response to exposure-based intervention components relevant to posttraumatic stress disorder (PTSD).

Key facts

Study ID
NCT07537764
Run by
Medical University of South Carolina
People needed
180
Starts
2026-09-01
Expected to finish
2031-03-01
Last updated by the study team
2026-05-08

Who can join

Age: 14 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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