The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Facial Paralysis, Peripheral, Bell's Palsy, Ocular Surface Disease

In brief

The purpose of this study is to explore the clinical efficacy of intradermal acupuncture in the treatment of ocular surface diseases after Intractable Facial Paralysis, and to seek effective and convenient treatment for ocular surface diseases after intractable peripheral facial paralysis. The main question it aims to answer is ： Will the intradermal acupuncture intervention effectively reduce the OSDI score ? The researchers compared the intradermal acupuncture with the placebo-needle to observe whether the intradermal acupuncture could better improve the symptoms.

Key facts

Study ID

NCT07537426

Run by

The First Affiliated Hospital of Zhejiang Chinese Medical University

People needed

78

Starts

2026-04-01

Expected to finish

2028-03-25

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1.Male or female patients aged 18-65 years.
• 2.Meets diagnostic criteria for intractable peripheral facial paralysis, with disease duration from 1 month to 1 year. FNGS 2.0 ≥15 points; ENoG shows the ratio of CMAP amplitude≤ 20%.
• 3.At least one subjective ocular symptom (dryness, foreign body sensation, burning, fatigue, redness, fluctuating vision) and OSDI scores between 30 and 80.
• 4.Voluntarily provides written informed consent and can comply with treatment and follow-up.

You may not qualify if…

• 1.Other ocular diseases (glaucoma, keratitis, retinopathy, acute inflammation of conjunctiva, sclera, cornea).
• 2. Intraocular surgery or laser therapy within the past 90 days.
• 3.Use of systemic or topical antibiotics or tear-affecting drugs within 3 weeks; dry eye medications within 2 weeks.
• 4.Lacrimal passage obstruction, dacryocystitis, punctal occlusion, or neurological impairment preventing full eyelid closure.
• 5.Coagulation disorders, open wounds, or local infection at intervention sites.
• 6.Allergy to press-needle materials (stainless steel, adhesive tape).
• 7.Pregnancy or lactation.
• 8.Severe cardiac, hepatic, renal, psychiatric disorders, or malignant tumors.
• 9.Participation in another clinical trial within the past month.

Where it is running

• The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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