Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia

Starting soon · Phase 4

Conditions studied: Community Acquired Pneumonia (CAP)

In brief

Aim: Demonstrate the equivalent efficacy and superior safety of Ceftriaxone 1 gram daily compared with Ceftriaxone 2 grams daily among hospitalized patients with community-acquired pneumonia who are not admitted to the intensive care unit.\<p\> Hypothesis: Among hospitalized patients outside of the intensive care unit with community-acquired pneumonia who are prescribed Ceftriaxone, a dosage of 1 gram daily will be associated with an equivalent rate of clinical cure and fewer adverse events than a dosage of 2 grams daily.

Key facts

Study ID

NCT07537413

Run by

University of Maryland, Baltimore

People needed

430

Starts

2026-09-01

Expected to finish

2028-02-28

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Evaluated in the emergency department or within 72 hours of hospitalization
• Prescribed Ceftriaxone for community-acquired pneumonia

You may not qualify if…

• Planned or present admission to an intensive care unit
• Respiratory failure requiring mechanical ventilation, non-invasive ventilation such as bilevel positive airway pressure, or high flow nasal cannula

Where it is running

• University of Maryland Medical Center - Midtown Campus — Baltimore, Maryland, United States
• University of Maryland Medical Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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