Preoperative Indomethacin and Paracetamol for Pain Management During Oocyte Retrieval in IVF Patients

Starting soon · Phase 4

Conditions studied: Pain, Oocyte Retrieval

In brief

This is a randomized controlled trial evaluating the efficacy of preoperative analgesic medications - Indomethacin (100 mg per rectum) and Paracetamol/Acamol (1,000 mg intravenously) - for pain management during oocyte retrieval in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

Key facts

Study ID

NCT07536425

Run by

Western Galilee Hospital-Nahariya

People needed

177

Starts

2026-04-13

Expected to finish

2027-12-31

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women undergoing oocyte retrieval for IVF or ICSI
• Age 18-45 years
• ASA physical status classification I or II
• Willing and able to provide written informed consent

You may not qualify if…

• Known allergy or hypersensitivity to Indomethacin, any NSAID, or Paracetamol
• History of gastrointestinal bleeding or peptic ulceration
• Renal impairment (GFR < 30 ml/min/1.73m² or Creatinine > 1.04 mg/dL)
• Hepatic impairment (ALT > 55 U/L, AST > upper limit of normal, ALP > upper limit of normal, Total Bilirubin > 1.2 mg/dL, or Albumin < 3.5 g/dL)
• Participation in another clinical trial that may interfere with the outcomes of this study

Where it is running

• Western Galilee Hospital, IVF unit — Nahariya, Israel

Full record on ClinicalTrials.gov

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