Effect of Adding PNF to IMT on Weaning Off MV

Starting soon · Not applicable

Conditions studied: Weaning From Mechanical Ventilation

In brief

the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation. the main question it aims to answer is is there a significant difference in the effect of inspiratory muscle training combined with PNF on the duration of weaning in the mechanically ventilated ICU patients. researchers will compare effect of (Inspiratory muscle training combined with PNF) to (Inspiratory muscle training) and control group. participants will be mechanically ventilated both sexes patients will be recruited in this study from intensive care unit, their ages older than 18 years. The selected patients will be mechanically ventilated due to respiratory failure and will randomly assigned into three equal groups.

Key facts

Study ID

NCT07536347

Run by

Beni-Suef University

People needed

93

Starts

2026-04-25

Expected to finish

2026-12-01

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults of both sexes
• patients older than 18 years
• Conscious and cooperative
• Hemodynamic stability without significant vasopressor support.
• No continuous sedation.
• Mechanically ventilated due to type 1 or type 2 respiratory failure (RF) for at least 24 hours.
• Mechanically ventilated in assisted ventilation mode
• Are able to participate in training actively, weanable as regard shallow breathing index.
• presence of weaning criteria as defined in the European Consensus Conference in 2007, including sedation reduction, spontaneous breathing cycles, Partial pressure of oxygen (PaO2)/ fraction of inspired oxygen (FiO2) ≥ 150, absence of inotropes or vasopressors at high doses or increasing doses (< 1 mg/h), oxy-hemoglobin saturation (SaO2) > 90% with FiO2≤ 50%, positive end expiratory pressure (PEEP) ≤ 8 cmH2O, temperature between 36 and 39 °C.

You may not qualify if…

• Hemodynamic or respiratory instability
• Condition that can compromise weaning, such as heart failure.
• Condition that can prevent adequate performance of inspiratory muscle training, such as neuropathy or myopathy.
• Thoracic or abdominal surgery precluding the use of PNF exercises
• Rib fractures
• Current pregnancy
• Cardiac arrest with a guarded neurological prognosis
• Deep coma

Full record on ClinicalTrials.gov

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