Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
Recruiting now
Conditions studied: Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases, Periodontal Attachment Loss
In brief
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Key facts
- Study ID
- NCT07536204
- Run by
- University of Chile
- People needed
- 30
- Starts
- 2023-06-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-04-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults
- Sistemically healthy
You may not qualify if…
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
- Diagnosis of diabetes
- Pregnancy or lactation
- More than 3 hospitalizations over the last 3 years
- Use of systemic antibiotics over the last 3 months
- Use of systemic corticosteroids or immunosuppressants over the last 3 months
- Use of cytokine therapy over the last 3 months
- Use of large doses of pre/probiotic supplements over the last 3 months
- Smoke more than 10 cigarettes per day
Where it is running
- Faculty of Dentistry, University of Chile — Santiago, Metropolitan Region, Chile (enrolling)
Full record on ClinicalTrials.gov
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