Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke

Starting soon

Conditions studied: Stroke, Acute Ischemic Stroke

In brief

The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with acute ischemic stroke (AIS) in routine clinical practice across China.

Key facts

Study ID

NCT07536165

Run by

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

People needed

3000

Starts

2026-04-01

Expected to finish

2029-12-01

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Age ≥ 18 years;
• 2. Clinical diagnosed of acute ischemic stroke;
• 3. Time from last known well (LKW) to initiation of intravenous thrombolysis > 4.5 hours (including wake-up stroke and unwitnessed stroke);
• 4. Received intravenous tenecteplase;
• 5. Provided written informed consent.

You may not qualify if…

• 1. Any condition judged by the investigator to make the participant unsuitable for study participation or follow-up (e.g., psychiatric disorders, cognitive impairment, or emotional disturbances).

Where it is running

• Sun Yat-sen Memorial Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China
• Liuyang Jili Hospital — Guankou, Hunan, China

Full record on ClinicalTrials.gov

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