Antihistamine for Prevention of HTR After Blood Primed CPB

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Blood Transfusion Associated Adverse Reactions

In brief

This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.

Key facts

Study ID

NCT07536152

Run by

Kasr El Aini Hospital

People needed

40

Starts

2026-03-01

Expected to finish

2026-12-01

Last updated by the study team

2026-04-21

Who can join

Age: 1 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acyanotic congenital heart disease.
• Age :1 -7 years.
• Genre: both.

You may not qualify if…

• Redo patient.
• History of allergy to antihistamines.
• Bleeding disorders with INR > 1.5 and/or platelets < 50,000.
• Emergency procedure.

Where it is running

• Misr Universty for Scince and Technology — Giza, October, Egypt (enrolling)

Full record on ClinicalTrials.gov

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