Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT
Enrolling by invitation · Not applicable
Conditions studied: Gingivitis
In brief
Frankincense, a natural resin obtained from trees of the Boswellia genus, has been traditionally used for its medicinal properties. It is well-documented for its antibacterial, anti-inflammatory, and analgesic effects, making it a candidate for therapeutic applications beyond its conventional uses. Despite its known pharmacological benefits, scientific evidence supporting the use of frankincense in oral health care, particularly in the management of periodontal diseases, remains limited. Gingivitis is one of the most common forms of gum disease, characterized by inflammation of the gingival tissues due to dental biofilm (plaque) accumulation. If left untreated, it can progress to periodontitis, leading to irreversible damage to the supporting structures of the teeth. Standard treatment approaches typically involve mechanical plaque control and the use of fluoride-based oral health care products, which are effective but may not be well-tolerated or preferred by all individuals. This study aims to explore the potential of frankincense-based oral care products as a natural alternative or adjunct to conventional oral products in the management of gingivitis. By comparing the clinical outcomes of patients using a frankincense-containing oral health care product with those using a commercially available oral care product, the study seeks to evaluate the effectiveness of frankincense in reducing gingival inflammation, dental biofilm (plaque) accumulation, and associated symptoms. Thus, improve oral health mainly by reducing gum inflammation. The findings could provide insights into the viability of incorporating natural products like frankincense into routine oral hygiene practice.
Key facts
- Study ID
- NCT07535229
- Run by
- Oman Dental College
- People needed
- 90
- Starts
- 2026-04-15
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-23
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Gingival index >1
- Periodontal pocket depth ≤ 3 mm
- Clinical attachment loss "0"
- Provision of written informed consent
- Good systemic health.
You may not qualify if…
- Severe periodontal disease, as characterized by purulent exudates, generalized mobility, and/or severe recession Any condition that requires antibiotic premedication for the administration of a dental prophylaxis.
- Self-reported pregnancy, intent to become pregnant during the study, or breast-feeding.
- Any diseases or condition that could be expected to interfere with the safe completion of the study.
- History of antibiotic use in the previous 3 months. Individuals with orthodontic appliances or prosthetic appliances that would interfere with evaluation.
Where it is running
- Oman Dental College — Muscat, Oman
Full record on ClinicalTrials.gov
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