Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment

Recruiting now · Not applicable

Conditions studied: IVF Patients, Female Infertility

In brief

The success rate after treatment by in-vitro fertilisation (IVF) strongly depends on the endometrial receptivity, which in turn is strictly connected to the endometrial immune profile. IVF outcome is largely dependent upon endometrial immune cell ratios and their relationship with one another. During the last few years there are several studies and case reports for intrauterine PRP application in patients resulting in a thicker, regenerated endometrium and better immune cell population ratios. In this project, the investigators aim to analyze the effect of autologous intrauterine PRP administration on the endometrial immune profile, endometrial thickness, selected hormone levels (E2, P4) during the mid-luteal phase and IVF outcomes (biochemical and clinical pregnancy).

Key facts

Study ID

NCT07535190

Run by

Nadezhda Women's Health Hospital

People needed

50

Starts

2026-01-19

Expected to finish

2028-06-01

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Participating in Assisted Reproduction Treatment
• Having infertility
• Having regular menstrual cycles
• Embryo transfer of euploid embryos

You may not qualify if…

• Uterine pathologies
• Endometrial Bacterial infections
• Active endometrial inflammation
• Polycystic ovary syndrome
• Cancer diagnostics
• Positive HIV, HCV or HBV tests
• Autoimmune diseases
• Recent immune therapy

Where it is running

• Nadezhda Women's Health Hospital — Sofia, Sofia, Bulgaria (enrolling)

Full record on ClinicalTrials.gov

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