Hepatoprotective Effects of Reishi Mushroom- (Ganoderma Lucidum) Among Metabolic Dysfunction-associated Fatty Liver Disease Patients

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Lipid Profile, Liver Biomarkers

In brief

This 12-week RCT investigates the hepatoprotective and immunomodulatory effects of Ganoderma lucidum combined with a probiotic-rich diet in adults with MAFLD, assessing liver enzymes, lipid profile, inflammation, gut microbiota, and oxidative stress. Findings are expected to show dose-dependent improvements in hepatic fat, insulin resistance, and inflammatory markers, potentially reducing reliance on pharmacotherapy in

Key facts

Study ID

NCT07534241

Run by

University of Lahore

People needed

102

Starts

2025-10-02

Expected to finish

2026-12-15

Last updated by the study team

2026-07-30

Who can join

Age: 35 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 35-65 years
• BMI between 18.5 and 30 kg/m².
• Complete Blood Count test ranges, WBC < 4,000-11,000 cells/µL, RBC Men < 4.5-6.0 / Women 4.0-5.5 million/µL, Hemoglobin: Men < 13.5-17.5 / Women 12.0-15.5 g/dL, Platelets < 150,000-450,000 cells/µL.
• Lipid profile test markers (elevated LDL, total cholesterol, or triglycerides less than 150mg/dL high 200-499mg/dL and 500 mg/dL are above high.
• Liver function test markers, ALT > 56 U/L, AST>40 U/L, ALP>147 UL.
• Inflammatory markers: CRP >3 mg/L, - IL-6 ≥3 pg/mL, TNF-α ≥8 pg/mL.
• Elevated blood sugar levels, or hyperglycemia, refer to a typically above 126 mg/dL, fasting or 200 mg/dL post-meal.

You may not qualify if…

• ● Diagnosed with severe cardiovascular disease, liver failure, or renal impairment.
• Pregnant or lactating women.
• Individuals currently on statins, ezetimibe, PCSK9 inhibitors, or any other lipid-lowering therapy.
• Allergic to mushrooms.
• Diagnosed with celiac disease or other chronic gastrointestinal disorders (e.g., Crohn's disease, ulcerative colitis).
• History of malignancy.
• Participation in another clinical trial within the last 3 months.

Where it is running

• Sana Noreen — Lahore, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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