Phase II Clinical Study of Probiotic LR607 in Patients With Non-Small Cell Lung Cancer
Recruiting now · Phase 2
Conditions studied: NSCLC Diagnosed by Histology or Cytology, A Multidisciplinary Team Assessment Determined That the Patient Was a Suitable Candidate for Radical Surgical Resection, Overall Lung Function is Adequate for the Planned Lung Resection, AJCC is Classified as IB-IIIC
In brief
The goal of this clinical trial is to understand whether Lactobacillus rhamnosus LR607 can enhance neoadjuvant chemoimmunotherapy for adult patients with non-small cell lung cancer. It will also evaluate the safety of LR607. The main questions it aims to answer include: Can LR607 improve the major pathological response of neoadjuvant chemoimmunotherapy? What is the relationship between LR607 combined with neoadjuvant chemoimmunotherapy and treatment-related adverse reactions? What changes occur in the gut microbiota composition at the species level and gut metabolites of subjects after LR607 treatment? Participants will: Take LR607 daily for 3 months Visit the hospital for check-ups and examinations every month Record their pathological response, tumor recurrence, and treatment-related adverse reactions
Key facts
- Study ID
- NCT07534033
- Run by
- Zhujiang Hospital
- People needed
- 46
- Starts
- 2025-12-06
- Expected to finish
- 2027-12-23
- Last updated by the study team
- 2026-04-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Histologically confirmed newly diagnosed patients
- ECOG performance status 0-1
- Age ≥18 years
- Measurable lesions (RECIST v1.1)
- Organ function meeting the requirements for chemotherapy and immunotherapy.
You may not qualify if…
- Including active autoimmune diseases
- Recent use of immunosuppressants
- Interstitial lung disease
- Presence of other malignancies
- History of immunotherapy
- Active infection
- Pregnancy or drug allergies
Where it is running
- Zhu Jiang Hospital of Southern Medical University — Guangzhou, China (enrolling)
Full record on ClinicalTrials.gov
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