Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery

Starting soon · Not applicable

Conditions studied: Perioperative Care, EEG Power Spectra, Delirium - Postoperative

In brief

The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks. The primary questions it aims to answer are: * Does a longer wake-up help participants think more clearly soon after surgery compared with usual approaches? * Does it lower pain scores, lower the amount of pain medications used, and shorten the time it takes to go home from recovery room? Researchers will compare 2 groups of adults who are having similar lower-extremity orthopaedic surgeries with regional and propofol anesthesia.

Key facts

Study ID

NCT07533370

Run by

Harrison Shong-Wen Chow

People needed

300

Starts

2026-07-01

Expected to finish

2027-10-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants with American Society of Anesthesiologists (ASA) physical status I-III
• Scheduled for Elective Foot/Ankle Orthopaedic surgery at Stanford Health under planned propofol-based intravenous anesthesia and regional nerve block for preoperative analgesia
• Able and willing to complete all cognitive assessments and Brice Interview in PACU

You may not qualify if…

• ASA physical status IV or V
• Chronic opioid therapy
• Chronic benzodiazepine use or ongoing treatment with strongly anticholinergic medications within 30 days prior to surgery.
• Known major neuro-cognitive disorder, active psychotic disorder, or other severe psychiatric condition that, in the opinion of the investigator, would interfere with valid cognitive testing.
• Active cardiac or neurological stimulators or pumps in use
• Severe uncorrected visual or hearing impairment that precludes valid cognitive battery or interview completion.
• Inability to speak and understand the study language sufficiently to provide informed consent and complete study assessments.
• Inability to provide informed consent or lack of a legally authorized representative when required.
• Concurrent participation in another interventional study that could confound PACU cognitive or delirium outcomes.

Where it is running

• Stanford Medicine Outpatient Center — Redwood City, California, United States

Full record on ClinicalTrials.gov

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