Comparing Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy

Starting soon · Not applicable

Conditions studied: Thyroidectomy

In brief

The goal of this interventional study is to compare the effectiveness of two surgical approaches in identifying the recurrent laryngeal nerve (RLN) during thyroidectomy. The main questions it aims to answer are: How does each approach affect the length of hospital stay? How does each approach affect the number of adverse events that occur during surgery? How does each approach affect vocal cord function after surgery? Researchers will compare the new medial approach to the standard lateral approach to evaluate its effectiveness. Participants scheduled to undergo thyroidectomy surgery will be randomly assigned to one of these approaches after informed consent is obtained. Data will be collected during and after the surgery by a research assistant.

Key facts

Study ID: NCT07532889
Run by: Oleksandr Butskiy
People needed: 430
Starts: 2026-05-01
Expected to finish: 2028-12-01
Last updated by the study team: 2026-04-21

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

All patients undergoing a total thyroidectomy or hemithyroidectomy under the care of the participating surgeons

You may not qualify if…

Age less than 19 years old
Previous thyroid or parathyroid surgery, substernal goiter, preoperative vocal cord palsy (VCP)
Evidence of lateral or central neck lymph node metastases
Intentional iatrogenic transection of the RLN due to tumor invasion
Failure to assess real-time RLN functioning due to equipment issues with the IONM setup
Presurgical dissection amplitude under 100uV
Patient refusal to participate in the study
Intraoperative decision to switch to a different approach to identifying the RLN

Full record on ClinicalTrials.gov

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