A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris

Recruiting now · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Lichen Planopilaris

In brief

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris

Key facts

Study ID

NCT07532603

Run by

Priovant Therapeutics, Inc.

People needed

342

Starts

2026-03-19

Expected to finish

2029-07-31

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Scalp biopsy consistent with LPP
• Active and symptomatic LPP at screening and baseline-
• Weight > 40 kg to < 130 kg with BMI ≤ 45 kg/m2

You may not qualify if…

• History of: Lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid cancer).
• High risk of thrombosis or cardiovascular disease
• High risk of herpes zoster
• Active or recent infection

Where it is running

• Clinical Trial Site — Phoenix, Arizona, United States (enrolling)
• Clinical Trial Site — Scottsdale, Arizona, United States (enrolling)
• Clinical Trial Site — Irvine, California, United States (enrolling)
• Clinical Trial Site — Oakland, California, United States (enrolling)
• Clinical Trial Site — Sacramento, California, United States (enrolling)
• Clinical Trial Site — San Francisco, California, United States (enrolling)
• Clinical Trial Site — Denver, Colorado, United States (enrolling)
• Clinical Trial Site — Farmington, Connecticut, United States (enrolling)
• Clinical Trial Site — New Haven, Connecticut, United States (enrolling)
• Clinical Trial Site — Miami, Florida, United States (enrolling)
• Clinical Trial Site — Chicago, Illinois, United States (enrolling)
• Clinical Trial Site — Skokie, Illinois, United States (enrolling)
• Clinical Trial Site — Clarksville, Indiana, United States (enrolling)
• Clinical Trial Site — Indianapolis, Indiana, United States (enrolling)
• Clinical Trial Site — Leawood, Kansas, United States (enrolling)
• Clinical Trial Site — Louisville, Kentucky, United States (enrolling)
• Clinical Trial Site — Boston, Massachusetts, United States (enrolling)
• Clinical Trial Site — Burlington, Massachusetts, United States (enrolling)
• Clinical Trial Site — Ann Arbor, Michigan, United States (enrolling)
• Clinical Trial Site — Ann Arbor, Michigan, United States (enrolling)
• Clinical Trial Site — Medina, Minnesota, United States (enrolling)
• Clinical Trial Site — Minneapolis, Minnesota, United States (enrolling)
• Clinical Trial Site — Kansas City, Missouri, United States (enrolling)
• Clinical Trial Site — Lee's Summit, Missouri, United States (enrolling)
• Clinical Trial Site — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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