Non-Invasive Transcutaneous Auricular Vagus Nerve Stimulation Applied at Different Durations in Healthy Adults
Starting soon · Not applicable · Has a placebo group
Conditions studied: Healthy Volunteers
In brief
This randomized, participant-blinded, sham-controlled interventional study aims to compare the acute effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) applied at different durations on autonomic nervous system responses in healthy adults. Participants will be assigned to either an active taVNS group or a sham stimulation group. Within each group, participants will complete three separate study visits in which stimulation will be applied for 5, 10, and 15 minutes in randomized order, with 48- to 72-hour washout intervals between visits. Heart rate variability, heart rate, blood pressure, respiratory rate, and subjective discomfort will be assessed immediately before and after each intervention session. The study is designed to determine whether the acute autonomic effects of taVNS vary according to stimulation duration and whether a duration-related response pattern can be identified.
Key facts
- Study ID
- NCT07532005
- Run by
- Sinop University
- People needed
- 44
- Starts
- 2026-05-01
- Expected to finish
- 2026-09-15
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy adults aged 18 to 40 years No known chronic systemic disease Non-smoker No regular medication use, including medications that may affect autonomic or cardiovascular function Able to understand the study procedures and provide written informed consent Willing to comply with study instructions and restrictions related to caffeine, alcohol, and strenuous exercise
You may not qualify if…
- Any known chronic systemic disease Current smoker Regular medication use, including medications that may affect autonomic or cardiovascular function Inability to understand the study procedures or provide written informed consent Unwillingness or inability to comply with study instructions and restrictions related to caffeine, alcohol, and strenuous exercise
Where it is running
- Artvin Coruh University, Artvin Vocational School, Disabled Care and Rehabilitation Laboratory — Artvin, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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