Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid
Recruiting now · Not applicable
Conditions studied: Cough Reflex Sensitivity
In brief
Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.
Key facts
- Study ID
- NCT07531901
- Run by
- University of Montana
- People needed
- 10
- Starts
- 2026-07-15
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older, up to 89. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy adults at least 18 years of age
- Consent to audio/video recording of the research sessions for research purposes
- Spirometry testing results obtained by study team on same day of first testing session with FEV1/FVC ratio and FEV1 percent predicted values of at least 0.70
You may not qualify if…
- Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session)
- Smoking of any substance in the last six months
- Diagnosed or suspected pulmonary disease (e.g., asthma, COPD)
- History of chronic cough
- History of head or neck cancer
- History of neurological disease (e.g., cerebrovascular accident)
- History of dysphagia (swallowing difficulty)
- Current complaint of a voice problem
- Current upper respiratory infection
Where it is running
- University of Montana — Missoula, Montana, United States (enrolling)
Full record on ClinicalTrials.gov
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