Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
Recruiting now
Conditions studied: Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease
In brief
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
Key facts
- Study ID
- NCT07531732
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 34
- Starts
- 2026-04-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-04-15
Who can join
Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR
- Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group)
- Mini-Mental State Examination (MMSE) ≥ 20
- Age: 50-80 years
- Sufficient reading and writing proficiency in French to enable completion of the study procedures, in the investigator's opinion
You may not qualify if…
- Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32
- Inability to perform computerized tasks according to the investigator's opinion
- Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia)
- Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode)
- Uncorrected visual impairment
Where it is running
- Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital Group, APHP — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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