Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy
Starting soon · Phase 4 · Has a placebo group
Conditions studied: Thyroidectomy, Sore Throat, Voice Quality
In brief
Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality. Participants will: * Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result * Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively * Undergo a visual analog scale for analgesia status at 6 hours postoperatively
Key facts
- Study ID
- NCT07531147
- Run by
- Izmir Katip Celebi University
- People needed
- 100
- Starts
- 2026-04-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- No history of neck surgery
- Age between 18-85 years
- Undergoing thyroidectomy
- Agreeing to participate in the study
- Operation duration between 60-120 minutes
You may not qualify if…
- History of neck surgery
- History of radiotherapy to the head and neck region
- Pre-operative or post-operative vocal cord paralysis
- Pre-operative phonetic disorder
- Pre-operative laryngeal pathology
- Being under 18 years of age
- Refusal to participate in the study
- Smoking
- Flurbiprofen allergy
- Lactose intolerance
Where it is running
- Izmir Katip Celebi University — Izmir, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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