Perioperative Pharmacokinetics of Anesthetic Drugs and Complications in Overweight and Obese Patients

Starting soon

Conditions studied: Obesity, Overweight

In brief

This observational study aims to investigate the impact of body composition on the absorption, distribution, and metabolism of anesthetic drugs, as well as on the incidence of complications in overweight and obese patients. The primary research question is whether specific body composition parameters in this population influence drug pharmacokinetics and complication rates. By integrating pharmacokinetic parameters, adverse drug reactions (ADRs), and clinical complications, the study will analyze variations in sufentanil kinetics under different body composition conditions. Under the guidance of research personnel, participants will undergo non-invasive body composition assessment using the nBody S10 analyzer. Key metrics collected will include, but are not limited to, mineral content, muscle mass, lean body mass (LBM), total body weight, and body fat percentage (BFP).

Key facts

Study ID

NCT07530848

Run by

Second Affiliated Hospital of Wenzhou Medical University

People needed

2100

Starts

2026-04-10

Expected to finish

2028-04-30

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18-65 years with ASA physical status I-III
• Participants were divided into a normal control group (18.5 < BMI < 23.9 kg/m²) and an experimental group (BMI > 24 kg/m²)
• Voluntary participation with written informed consent approved by the Ethics Committee
• No cognitive or verbal communication impairments, with the ability to fully cooperate with the study procedures

You may not qualify if…

• 1: Severe organ dysfunction, including severe hepatic or renal insufficiency, unstable coronary syndrome, uncontrolled hypertension, and other severe cardiovascular diseases
• 2: History of chronic pain or long-term use of opioids/sedatives; preoperative use of potent CYP3A inhibitors or inducers
• 3: Contraindications to body composition measurement via Bioelectrical Impedance Analysis (BIA), including abdominal wall stoma, massive ascites, limb amputation/absence, and presence of cardiac pacemakers or implantable cardioverter-defibrillators (ICDs)
• 4: Women who were pregnant or breastfeeding were excluded from the study
• 5: Known hypersensitivity or allergy to study medications
• 6: Any other condition deemed by the investigator to make the patient unsuitable for participation, including but not limited to severe psychiatric disorders or legal restrictions

Where it is running

• The Second Affiliated Hospital and Yuying Children's Hospital Affiliated to Wenzhou Medical University第二附属医院和温州医科大学附属的玉英儿童医院 — Wenzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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