The Exercogs® Study

Recruiting now · Not applicable

Conditions studied: Dementia

In brief

Background: Multidomain, technology-based interventions represent a promising approach to dementia prevention by simultaneously targeting cognitive, physical, and social domains. Exercogs® is a novel exergaming platform combining augmented reality (AR) and gamification, designed to deliver tailored, interactive, and multidomain training. This study aims to evaluate the feasibility, safety, and efficacy of Exercogs® when implemented as part of a community-based dementia prevention program for older adults at risk. Methods: This is a randomized, controlled, assessor-blind, parallel-group, multicenter trial. One hundred and fifty community-dwelling adults, aged 55 years or older, with at least one modifiable dementia risk factor, will be randomly assigned (1:1) to either the Exercogs® intervention group or the active control group. Both groups will complete 60-minute supervised sessions three times per week for 24 weeks. The Exercogs® program integrates cognitive (e.g., attention, memory, and executive function), physical (e.g., balance, gait, and coordination), and social (e.g., cooperative and competitive) activities within a gamified AR environment. The difficulty levels are adaptable to the participants' individual abilities. The control group will perform equivalent non-AR exercises, i.e., the control group will receive a conventional multidomain group program with the same frequency and duration. Outcomes will be assessed at baseline, 12 weeks, 24 weeks (end of intervention), and 4 and 8 weeks post-intervention. The co-primary endpoints are changes in global cognition (Montreal Cognitive Assessment-Portuguese Version, MoCA-PT), physical performance (Short Physical Performance Battery, SPPB), and social participation (World Health Organization Disability Assessment Schedule, WHODAS 2.0). Secondary outcomes include usability (System Usability Scale, SUS-PT; Exercogs® group only), health-related quality of life (EQ-5D-5L), safety (adverse events, including falls, dizziness, and fatigue), and changes in modifiable risk load. Exploratory outcomes include digital engagement and in-game performance metrics automatically captured by the Exercogs® platform. Feasibility will be assessed by session adherence (≥70% completion). Results: The protocol has been approved by the Casa de Saúde da Idanha Ethics Committee (Nº6/2025) and funded by the Instituto da Segurança Social, I.P. Preliminary findings are expected in 2026 and will provide comprehensive evidence on the efficacy, feasibility, usability, and safety of Exercogs® as a multidomain digital intervention. Conclusions: This trial will evaluate a scalable, technology-driven, multidomain intervention for older adults at risk of dementia, integrating cognitive, physical, and social training within an AR environment and gamification. If effective, Exercogs® could serve as a model for community-based dementia prevention and inform public health strategies for healthy aging.

Key facts

Study ID: NCT07530315
Run by: Eduarda Oliosi, MS
People needed: 150
Starts: 2026-01-01
Expected to finish: 2027-12-01
Last updated by the study team: 2026-04-15

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age 55 years or older
Presence of ≥1 modifiable risk factor according to the Lancet Commission on Dementia Prevention, Intervention, and Care (2024): low education, untreated hearing or visual loss, hypertension, obesity, smoking, depression, physical inactivity, type 2 diabetes, social isolation, excessive alcohol consumption, history of head trauma, air pollution exposure, high LDL/dyslipidemia; additional social and structural determinants, including poverty, income inequality, wealth shocks, and HIV, that may also contribute to risk (Mostert et al., 2025);
Ability and willingness to participate in 60-minute sessions, three times per week, during the 24-week intervention period;
Ability to provide written informed consent, or, in cases of reduced decisional capacity, provision of consent by a legally authorized representative.

You may not qualify if…

Clinical diagnosis of Alzheimer's disease or dementia;
Severe neurological disorder or unstable medical condition that may interfere with participation;
Sensory or language deficits that would prevent understanding of instructions or safe participation;
Current participation in another interventional study that may confound outcomes (e.g., cognitive training, physical exercise, or multidomain rehabilitation);
Previous experience with Exercogs®.

Where it is running

Irmãs Hospitaleiras - Casa de Saúde da Idanha — Sintra, Portugal (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.