Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Secondary Peritonitis, Post-induction Hypotension

In brief

This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis. Adults with secondary peritonitis who are scheduled for emergency surgery and have stable blood pressure after initial resuscitation will be randomly assigned to receive either norepinephrine or placebo (normal saline) during induction of anesthesia. The main outcome is the cumulative time spent with mean arterial pressure (MAP) below 65 mmHg from the start of propofol administration to 10 minutes after endotracheal intubation. The study will also evaluate rescue vasopressor use, heart rate changes, drug-related adverse events, and selected early postoperative outcomes.

Key facts

Study ID

NCT07529795

Run by

Bach Mai Hospital

People needed

60

Starts

2026-04-01

Expected to finish

2026-10-01

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older.
• Secondary peritonitis requiring emergency surgery under general anesthesia with endotracheal intubation.
• Planned induction with fentanyl, propofol, and rocuronium according to the study protocol.
• Hemodynamically stabilized after initial resuscitation, with MAP at least 65 mmHg and no ongoing vasopressor infusion before induction.
• ASA physical status I to III.
• Written informed consent from the participant or a legally authorized representative.

You may not qualify if…

• Allergy or contraindication to norepinephrine, propofol, fentanyl, or rocuronium.
• Severe cardiovascular disease likely to confound hemodynamic assessment, including decompensated heart failure, acute coronary syndrome, severe arrhythmia, severe valvular disease, or major cardiomyopathy.
• Ongoing vasopressor therapy before induction.
• Shock before surgery, including hypovolemic, septic, or cardiogenic shock.
• Severe hypertension before induction (systolic blood pressure >180 mmHg or mean arterial pressure >110 mmHg).
• Severe peripheral vascular disease or clinically significant limb ischemia.
• Current monoamine oxidase inhibitor use.
• Pregnancy or breastfeeding.
• Contraindication to arterial catheter placement.
• Refusal of consent.

Where it is running

• Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital — Hanoi, Vietnam

Full record on ClinicalTrials.gov

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