Adults With Constipation
Starting soon · Not applicable · Has a placebo group
Conditions studied: Constipation
In brief
This randomized, double-blind, placebo-controlled trial will assess the clinical effects of Akk09 in adults with functional constipation. Participants will receive Akk09 or placebo for 8 weeks. The study will evaluate changes in bowel habits and symptom burden, as well as alterations in host inflammatory status, immune modulation, microbial ecosystem dynamics, neuroendocrine signaling related to the gut-brain axis, and systemic metabolic responses, to characterize the overall physiological impact of Akk09 supplementation.
Key facts
- Study ID
- NCT07529457
- Run by
- Wecare Probiotics Co., Ltd.
- People needed
- 70
- Starts
- 2026-07-24
- Expected to finish
- 2027-05-20
- Last updated by the study team
- 2026-07-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women aged between 18 and 65 years;
- Participants presenting with constipation, characterized by <3 spontaneous bowel movements per week or BSFS stool types 1-2;
- Capable of following the study protocol and completing all required assessments; Individuals who have voluntarily signed the informed consent form;
- No plans for pregnancy from at least 14 days prior to screening through 6 months after the study, with agreement to use reliable contraception methods.
You may not qualify if…
- Intake of similar functional products within a short period prior to enrollment that could influence study results;
- Participants who significantly alter their habitual diet during the trial;
- Individuals with severe allergic conditions or impaired immune function;
- Women who are pregnant, lactating, or intending to conceive;
- Patients with serious underlying diseases affecting major organs or metabolic systems;
- Antibiotic treatment within 2 weeks before enrollment;
- Individuals with severe mental or psychological disorders;
- Non-compliance with study requirements, including improper intake or missed follow-ups;
- Other subjects considered inappropriate for participation by the investigator.
Where it is running
- Suzhou Ninth People's Hospital — Suzhou, Jiangsu, China
Full record on ClinicalTrials.gov
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