Study of Hyaluronic Acid Used With Gum Surgery to Treat Gum Recession in Adults

Starting soon · Not applicable

Conditions studied: Gingival Recession, Mucogingival Surgery

In brief

Gingival recession is a common condition in which the gum tissue recedes, exposing the root surface of the tooth. This can lead to tooth sensitivity, higher risk of root decay, and aesthetic concerns. A commonly used surgical treatment is the coronally advanced flap combined with a connective tissue graft (CAF + SCTG), which aims to cover the exposed root and improve gum health. Hyaluronic acid (HA) is a naturally occurring substance in the body that plays an important role in wound healing. It may help improve tissue repair, reduce inflammation, and enhance healing after surgery. This study aims to evaluate whether the use of hyaluronic acid (hyaDENT BG®) in addition to standard surgical treatment improves clinical outcomes in patients with gingival recession. Participants will be randomly assigned to receive either standard treatment alone or standard treatment with hyaluronic acid. The main outcome is the proportion of sites with complete root coverage after 12 months. Additional outcomes include healing, gum tissue improvement, patient-reported pain and discomfort, and aesthetic results. The study also includes a laboratory component to investigate how hyaluronic acid affects cells involved in gum healing.

Key facts

Study ID

NCT07529340

Run by

Universidade do Porto

People needed

34

Starts

2026-05-01

Expected to finish

2027-09-01

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Age ≥ 18 years, in good general health (ASA I or II)
• Presence of a single gingival recession defect classified as RT1 or RT2
• Recession depth ≥ 2 mm with identifiable cemento-enamel junction (CEJ)
• Presence of at least 1 mm of keratinized tissue at the defect site
• No active periodontal disease (probing depth ≤ 4 mm and no bleeding on probing at the selected tooth)
• Full-Mouth Plaque Score (FMPS ≤ 20%) and Full-Mouth Bleeding Score (FMBS ≤ 20%)
• Vital tooth without caries, cervical lesions, or defective restorations
• Good oral hygiene and motivation to maintain plaque control
• Ability and willingness to comply with study procedures
• Signed informed consent

You may not qualify if…

• Uncontrolled systemic diseases (e.g., uncontrolled diabetes, severe cardiovascular disease, immunodeficiency)
• Pregnant or breastfeeding women
• Autoimmune diseases or immunosuppressive therapy
• Known hypersensitivity to hyaluronic acid
• Heavy smokers (>10 cigarettes/day) or recent tobacco use
• Active periodontal disease at the study site
• Caries, root fractures, endodontic lesions, or defective restorations at the study tooth
• Previous mucogingival surgery at the study site
• Recent use of antibiotics, corticosteroids, or anti-inflammatory drugs
• Coagulation disorders or anticoagulant therapy contraindicating surgery
• Hormonal disorders affecting wound healing
• Acute oral infections
• Any condition that may interfere with study participation or follow-up

Where it is running

• CEPI - Clinical Center for Periodontology and Implantology — Porto, Porto District, Portugal

Full record on ClinicalTrials.gov

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