Novel 3-dimensional Echocardiographic Quantification of Mitral Regurgitant Volume

Recruiting now

Conditions studied: Moderate or Severe Mitral Regurgitation

In brief

The goal of this observational study is demonstrate that a novel artificial intelligence based software for the quantification of the mitral regurgitation on 3-dimensional transesophageal echocardiography (3D CFQ) is more reproducible and accurate than the conventional assessment of mitral regurgitation performed with 2-dimensional echocardiography. The main question aims to answer is to demonstrate the agreement between 3D-CFQ measurement of the mitral regurgitant volume and the cardiac magnetic resonance measurement of the regurgitant volume is better than the agreement between 2-dimensional echocardiography and cardiac magnetic resonance. If this is demonstrated, we would like to test the accuracy of this tool to be applied in acute settings such as transcatheter interventions to decide the therapy to follow. Participants will undergo clinically indicated transesophageal echocardiography to characterize the mechanism and severity of mitral regurgitation and to cardiac magnetic resonance to be used as reference stadard to define the mitral regurgitation severity.

Key facts

Study ID

NCT07528781

Run by

Germans Trias i Pujol Hospital

People needed

200

Starts

2026-03-17

Expected to finish

2028-04-01

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with at least moderate mitral regurgitation of any etiology
• Patients with good transesophageal echocardiography image quality

You may not qualify if…

• Patients with prior transcatheter or surgical mitral valve intervention
• Patients with contraindications for transesophageal echocardiography or cardiac magnetic resonance

Where it is running

• Hospital University Germans Trias i Pujol — Badalona, Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.