Gemcitabine vs Paclitaxel in Caribbean Women of African Ancestry With Metastatic Triple-Negative Breast Cancer

Starting soon · Phase 2

Conditions studied: Triple Negative Breast Cancer, Metastatic Triple-negative Breast Cancer

In brief

The goal of this clinical trial is to learn if Gemcitabine, a chemotherapy drug that is usually used to treat breast cancer after other treatments have failed, is better at treating triple negative breast cancer in Black Caribbean women than Paclitaxel, one of the chemotherapy drugs that is usually used first. People will be invited to participate in the trial if they are Caribbean women of African ancestry, are 18 years or older, have had a biopsy that shows that they have triple negative breast cancer (TNBC), and are willing to take part. The main questions the trial aims to answer are: 1. Does Gemcitabine stop triple negative breast cancer from growing or spreading better than Paclitaxel? 2. Are participants more likely to get better when taking Gemcitabine or Paclitaxel? 3. What medical problems do participants have when taking Gemcitabine for breast cancer? 4. Do Gemcitabine and Paclitaxel affect Black Caribbean women differently than women from other regions or ethnic groups? To answer these questions, half of participants will be treated with Gemcitabine while half is treated with Paclitaxel. Both drugs are given by injection and have already been approved for breast cancer treatment. Participants will: * Take Gemcitabine for two weeks followed by a two-week break, or take Paclitaxel once a week for the same time period. * Have some of the cancer tissue that was tested from their biopsy taken for more testing. * Have a physical exam and a blood test done every 3 weeks. * Have images of their cancer taken using CT (Computed Tomography) or MRI (Magnetic Resonance Imaging) every 6 weeks. * Answer a brief questionnaire about how they are feeling every 8 weeks. * Be checked on every month after treatment is finished to make sure the cancer hasn't come back.

Key facts

Study ID

NCT07528768

Run by

AntiCancer Research Jamaica

People needed

750

Starts

2026-06-01

Expected to finish

2034-06-01

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Self-identified Caribbean Black women of Jamaican, Trinidadian, or Barbadian ancestry
• Age ≥18 years
• Histologically confirmed metastatic triple-negative breast cancer (recent biopsy required)
• ECOG (Eastern Cooperative Oncology Group) performance status 0-1
• No prior systemic therapy for metastatic disease
• Adequate organ function (detailed laboratory criteria specified)
• Written informed consent
• Willingness to provide biospecimens for research

You may not qualify if…

• Prior gemcitabine, anthracycline, or taxane treatment in any setting
• Active brain metastases requiring immediate treatment
• Pregnant or breastfeeding
• Concurrent participation in other interventional trials
• Medical conditions precluding safe chemotherapy administration
• Inability to provide informed consent

Where it is running

• The Queen Elizabeth Hospital — Bridgetown, Saint Michael, Barbados
• The University of the West Indies, Mona — Mona, Kingston, Jamaica
• St. James Medical Complex — Port of Spain, Saint James, Trinidad and Tobago

Full record on ClinicalTrials.gov

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