An Observational, Multicenter Study to Evaluate the Effectiveness of Guselkumab for the Treatment of Participants With Crohn's Disease After Surgical Resection

Starting soon

Conditions studied: Crohn's Disease (CD)

In brief

The goal of this single arm ,non-interventional, prospective, descriptive study is to evaluate the efficacy of guselkumab treatment in preventing endoscopic recurrence of Crohn's Disease in adult participants who have a documented diagnosis of moderate to severe CD and have undergone an ileocolonic surgical resection. The primary endpoint is Endoscopic recurrence rate at week24.

Key facts

Study ID

NCT07528040

Run by

Shanghai 10th People's Hospital

People needed

88

Starts

2026-04-15

Expected to finish

2029-05-31

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients≥ 18，
• Have a documented diagnosis of moderate to severe CD
• Have undergone an ileocolonic surgical resection

You may not qualify if…

• Has complications of CD, such as short bowel syndrome Currently has or is suspected to have an abscess
• Active infection
• Currently has a malignancy or has a history of malignancy within 5 years

Where it is running

• Shanghai 10th People's Hospital, Tongji University School of Medicine — Shanghai, China

Full record on ClinicalTrials.gov

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