Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer
Recruiting now · Phase 2
Conditions studied: Advanced Microsatellite Stable Colorectal Cancer
In brief
The goal of this clinical study is to learn more about the study drug, Denikitug (DEN, GS-1811), to evaluate the efficacy and safety of Denikitug Monotherapy and Denikitug-based Combinations in participants with advanced microsatellite stable (MSS) colorectal cancer (CRC). The primary objective of this study is to assess the effect of DEN as monotherapy and in combination with nivolumab (NIVO) or trifluridine-tipiracil (FTD-TPI) and bevacizumab (BVZ) on objective response rate (ORR) as assessed by the investigator according to Response Evaluation Criteria in Solid Tumors (RECIST Version 1.1).
Key facts
- Study ID
- NCT07527858
- Run by
- Gilead Sciences
- People needed
- 170
- Starts
- 2026-05-19
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-07-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yale-New Haven Hospital - Yale Cancer Center — North Haven, Connecticut, United States (enrolling)
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States (enrolling)
- Avera Cancer Institute — Sioux Falls, South Dakota, United States (enrolling)
- University of Virginia, — Charlottesville, Virginia, United States (enrolling)
- Chris O'Brien Lifehouse — Camperdown, CA, Australia (enrolling)
- Royal Brisbane and Women's Hospital — Herston, Queensland, Australia (enrolling)
- Peter MacCallum Cancer Centre — Melbourne, Victoria, Australia (enrolling)
- Asan Medical Center — Seoul, South Korea
- Hospital General Universitario Gregorio Maranon — Madrid, Spain
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Samsung Medical Center — Busan, South Korea
- Seoul National University Hospital — Seoul, South Korea
- Yonsei University Severance Hospital ( aka Yonsei Cancer Center) — Seoul, South Korea
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.