Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques

Recruiting now · Not applicable

Conditions studied: Healthy Participants

In brief

This study investigates short-term intra- and inter-individual variability in human blood metabolism under real-life conditions. Using minimally invasive finger-prick blood sampling, dietary records, and wearable devices, we will longitudinally monitor blood-circulating metabolites and glucose levels in healthy individuals over a four-week period without dietary or lifestyle intervention. The study focuses on metabolic transitions between pre- and postprandial states during habitual daily activities and routine meals. Mass spectrometry-based metabolomics will be used to characterize metabolite profiles and their associations with diet, physical activity, sleep, and stress. In parallel, the study evaluates the feasibility of microsampling approaches, wearable-derived physiological data, and isotope-labelled standards for robust and cost-effective metabolite quantification. The results will inform the design of larger longitudinal studies using minimally invasive blood sampling in non-controlled settings.

Key facts

Study ID

NCT07527793

Run by

Örebro University, Sweden

People needed

35

Starts

2026-01-21

Expected to finish

2026-12-31

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 18-65 years old
• Body Mass Index (BMI): 18.5-29.9 kg/m2
• Weight stability within the previous 3 months (self-reported).
• Positive intention to maintain usual routine physical activity and eating habits during the study.

You may not qualify if…

• Presence of acute chronic diseases, inflammatory or functional gastrointestinal disorders, or any diagnosed disease condition that disrupt daily routine activities.
• Routine use medications or supplements that could potentially interfere with the study outcomes
• History of eating disorder
• Recent use of antibiotic medication within the last 3 months prior to the first visit
• Active efforts to lose weight
• Smoking
• Consumption of alcoholic drinks exceeding nine standard cups per week and/or more than three standard cups per occasion

Where it is running

• School of Medical Sciences — Örebro, Sweden (enrolling)

Full record on ClinicalTrials.gov

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