Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.
Starting soon · Phase 2
Conditions studied: Posterior Urethral Valves
In brief
Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared with antibiotic prophylaxis alone. This multicenter randomised controlled trial prospectively compares circumcision alone with circumcision plus antibiotic prophylaxis for the prevention of fUTIs in boys with PUV, enriched with external historical data from the CIRCUP trial)
Key facts
- Study ID
- NCT07527442
- Run by
- University Hospital, Bordeaux
- People needed
- 72
- Starts
- 2026-04-13
- Expected to finish
- 2032-04-13
- Last updated by the study team
- 2026-04-14
Who can join
Age: 0 and older, up to 0. Sex: male. Healthy volunteers: not accepted.
Where it is running
- CHU de Besançon — Besançon, France
- CHU de Bordeaux — Bordeaux, France
- CHU de Limoges — Limoges, France
- APHM — Marseille, France
- CHU de Montpellier — Montpellier, France
- CHU de Nantes — Nantes, France
- APHP Hôpital Armand Trousseau — Paris, France
- APHP Hôpital Necker — Paris, France
- APHP Hôpital Robert Debré — Paris, France
- CHU de Reims — Reims, France
- CHU de Rennes — Rennes, France
- CHU de la Réunion — Saint-Denis, France
- CHU de Toulouse — Toulouse, France
Full record on ClinicalTrials.gov
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