Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Obesity
In brief
The purpose of this clinical study is to look into how study medicines CagriSema (cagrilintide and semaglutide), cagrilintide, and semaglutide affects muscle health in people with excess body weight and slightly higher than normal blood sugar as they lose weight. Participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to treat people with type 2 diabetes and excess body weight) or placebo (a placebo looks like the treatment being tested but doesn't have any active ingredients in it). Which treatment participants will get is decided by chance. Participants will be in this clinical study up to 15 months.
Key facts
- Study ID
- NCT07527195
- Run by
- Novo Nordisk A/S
- People needed
- 100
- Starts
- 2026-04-10
- Expected to finish
- 2028-06-09
- Last updated by the study team
- 2026-05-07
Who can join
Age: 50 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female.
- Age 50-70 years (both inclusive) at the time of signing the informed consent.
- Body Mass index (BMI) between 30.0 kilograms per square meter (kg/m\^2) and 39.9 kg/m\^2 (both inclusive) at screening (V1).
- Excess body weight should be due to excess adipose tissue, as judged by the investigator.
- Participant has a wish to lose at least 25 percentage (%) of body weight within 52 weeks of treatment.
You may not qualify if…
- Any leg amputations.
- Female participants who are not postmenopausal at screening.
- Any clinically significant body weight change (greater than or equal to [>=] 5% self-reported change) or dieting attempts within 90 days before screening.
- Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist or a medication with GLP-1 activity within 90 days before screening.
Where it is running
- Aarhus Universitetshospital, Steno Diabetes Center Aarhus — Aarhus N, Denmark (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.