Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke
Starting soon · Phase 3
Conditions studied: Endovascular Therapy, Acute Ischaemic Stroke, Collateral Circulation, Blood Pressure Management, Prognosis
In brief
The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful recanalization, the evaluation will compare a stratified blood pressure management strategy based on the collateral circulation status with the guideline-recommended conventional blood pressure management strategy. Within each stratum, participants will be randomized in a 1:1 ratio to either the stratified blood pressure management strategy group or the guideline-recommended conventional blood pressure management group. The goal is to determine whether this can improve good functional outcomes at 90 days (90-day Modified Rankin Scale \[mRS\] score 0-2). The study consists of four visits including the day of randomization, 24±4 hours after randomization, 7±1 days after randomization and 90±7 days after randomization. Demographic information, symptoms and signs, laboratory test, neuro-imaging assessment, neurological function rating scale will be recorded during the program. The primary outcome is the modified Rankin Scale (mRS) score of 0 to 2 at 90±7 days after randomization. The primary safety outcome is the incidence of sICH within 24±4 hours after randomization.
Key facts
- Study ID
- NCT07527013
- Run by
- Beijing Tiantan Hospital
- People needed
- 544
- Starts
- 2026-06-01
- Expected to finish
- 2028-02-29
- Last updated by the study team
- 2026-04-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years；
- Clinical diagnosis of acute ischemic stroke caused by anterior circulation large vessel occlusion (internal carotid artery or M1/M2 segment of the middle cerebral artery)；
- Received EVT (including direct EVT and bridging therapy) within 24 hours of symptom onset；
- Baseline ASPECTS score ≥ 3；
- Baseline NIHSS score ≥ 6；
- Successful recanalization achieved post-procedure (defined as expanded Thrombolysis in Cerebral Infarction [eTICI] grade ≥ 2b50);
- Two consecutive systolic blood pressure (SBP) measurements ≥ 150 mmHg within 3 hours post-recanalization (with a measurement interval of no less than 5 minutes)；
- Able to complete randomization within 3 hours post-recanalization；
- Informed consent signed by the patient or their legal representative.
You may not qualify if…
- Pre-stroke mRS score > 1；
- Comatose state (Glasgow Coma Scale [GCS] score < 8);
- Symptomatic intracerebral hemorrhage occurred before randomization;
- Within the past 3 months, occurrence of acute ST-segment elevation myocardial infarction (MI), acute decompensated heart failure, QTc > 500 ms, hospitalization or involuntary coronary intervention due to acute coronary syndrome, MI, or cardiac arrest; or heart failure (New York Heart Association [NYHA] class III/IV or left ventricular ejection fraction < 35%); or known history of ventricular tachycardia;
- History of severe renal insufficiency, acute renal failure, dialysis, or estimated glomerular filtration rate (eGFR) < 20 ml/min/1.72m²;
- History of severe hepatic disease, or Aspartate Aminotransferase (AST) and/or Alanine Aminotransferase (ALT) and/or Gamma-Glutamyl Transferase (GGT) ≥ 3×ULN and/or Total Bilirubin (TBIL) ≥ 2×ULN;
- Aortic dissection, cervical artery dissection, or cerebral artery dissection; unruptured aortic aneurysm or cerebral aneurysm; or known arteriovenous malformation;
- Comorbidities with a life expectancy < 6 months (e.g., malignant tumors);
- Pregnant or lactating women;
- Participation in another clinical trial within the past 30 days;
- Any clinical condition judged by the research team that might limit compliance with study procedures.
Where it is running
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing Municipality, China
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.