Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises

Recruiting now · Not applicable

Conditions studied: Phenylketonuria

In brief

This study will be the first in the literature to evaluate the relationship between aerobic and resistance exercises, plasma amino acid levels, metabolic control of patients, and the metabolic response to exercise with different types of meals in patients with Phenylketonuria (PKU). In patients with phenylketonuria, the aim is to determine which pre-exercise dietary recommendations are more physiologically appropriate and ideal for achieving good metabolic control. In the literature, there are very few studies examining the effects of exercise on plasma amino acid levels and metabolic parameters in PKU patients.

Key facts

Study ID

NCT07526909

Run by

Hacettepe University

People needed

10

Starts

2025-10-01

Expected to finish

2026-07-15

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be over 18 years old,
• Having a classic FKU diagnosis,
• Not being actively engaged in sports,
• Not having any other existing diseases,
• Not having an active infection,
• Have a BMI in the range of 20-28 kg/m2 within the last 3 months,
• Agreeing to consume test meals and provide blood samples for parameters that will evaluate plasma amino acid levels as part of the research
• Being willing to participate in this study

You may not qualify if…

• Presence of a chronic disease accompanying FKU disease (endocrine, etc.)
• The individual with FKU has mental retardation or is deemed unfit for work based on psychomotor assessment,
• Recent weight loss, history of hospitalisation, a past infection, or a diagnosed illness
• Use of drugs or alcohol that alter protein and energy metabolism (e.g., corticosteroids, etc.)
• Pregnancy status
• Smoking habits The considerations to be taken into account when planning the day/date of the test are as follows.
• Having engaged in heavy exercise or sports within 24 hours before the application of test diets,
• Being in the menstrual period for female patients.

Where it is running

• Hacettepe University — Ankara, Ankara, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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