Effect of Instrumentation Systems and Sealers on Postoperative Pain
Starting soon · Not applicable
Conditions studied: Irriversible Pulpitis
In brief
The goal of this randomized clinical trial is to evaluate whether different root canal preparation systems and sealer types affect postoperative pain after root canal treatment in adult patients (18-60 years) with asymptomatic irreversible pulpitis in mandibular premolars. The main questions it aims to answer are: Do different instrumentation systems (TruNatomy vs ProTaper Gold) influence postoperative pain levels? Do different sealer types (AH Plus vs TotalFill BC) affect postoperative pain and analgesic consumption? Researchers will compare TruNatomy and ProTaper Gold systems combined with AH Plus or TotalFill BC sealers to determine their effect on postoperative pain. Participants will: Undergo single-visit root canal treatment using one of the assigned file system and sealer combinations Record their pain levels using a Numerical Rating Scale (NRS) at specific time intervals (6, 12, 24, 48, 72 hours, and 7 days) Take ibuprofen only if needed and record analgesic intake Attend a follow-up visit on the 7th day
Key facts
- Study ID
- NCT07526844
- Run by
- European University of Lefke
- People needed
- 144
- Starts
- 2026-07-01
- Expected to finish
- 2027-10-30
- Last updated by the study team
- 2026-04-21
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Asymptomatic teeth with delayed positive response to thermal and electric pulp testing
- Vital teeth with signs of irreversible pulpitis
- Mature mandibular first or second premolars
- Periodontally healthy teeth Exclusion Criteria
- Patients with systemic conditions (e.g., diabetes, immunocompromised status, pregnancy)
- Antibiotic use within the past month
- Use of analgesics within 7 days prior to treatment
- Known allergy to materials used
- Teeth with periapical lesions
- Non-vital or symptomatic teeth
- Teeth requiring post-core restorations
- Calcified canals, root resorption, or immature teeth
Full record on ClinicalTrials.gov
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