Concomitant Trans-Perineal Prostate Biopsy and Ablation (Bioblation) for Prostate Cancer
Starting soon · Not applicable
Conditions studied: Prostate Cancer, Lower Urinary Tract Symptoms (LUTS), Benign Prostatic Hyperplasia
In brief
This prospective study aims to validate the clinical outcomes of performing a concomitant trans-perineal prostate biopsy and laser ablation (termed "Bioblation") during a single session. The intervention is designed for symptomatic patients presenting with lower urinary tract symptoms (LUTS) who are highly suspected to have low to favorable intermediate-risk prostate cancer. By combining diagnosis and targeted treatment under local anesthesia, this approach seeks to facilitate early relief of severe symptoms and a rapid return to daily activities. Ultimately, the study evaluates whether this combined procedure decreases the patient's exposure to multiple, temporally separated interventions without compromising oncological safety or efficacy.
Key facts
- Study ID
- NCT07526675
- Run by
- Benha University
- People needed
- 30
- Starts
- 2026-04-10
- Expected to finish
- 2026-04-28
- Last updated by the study team
- 2026-04-13
Who can join
Age: 2 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Patients with severe Lower Urinary Tract Symptoms (LUTS) meeting the following parameters:
- IPSS score > 20
- Uroflowmetry flow rate < 10 ml/sec
- Post-void residual > 150 cc
- Patients most probably having low to favorable intermediate-risk prostate cancer, defined as:
- PSA level between 4 and 20 ng/ml
- MP-MRI showing 3 or fewer focal lesions
- MP-MRI focal lesions measuring < 1.5 cm
- International or visiting patients requiring early return to their home country due to professional or personal commitments, provided they can undergo short-term management and follow-up coordination
You may not qualify if…
- Patient PSA level > 20 ng/ml
- More than 3 focal lesions on MP-MRI
- Metastatic prostate cancer
- History of lower urinary tract surgery (e.g., TURP, Laser, urinary diversions, artificial urinary sphincter)
- History of pelvic radiation therapy or radical pelvic surgery
Where it is running
- Urology Department, Benha University Hospitals — Banhā, Qalyubia Governorate, Egypt
Full record on ClinicalTrials.gov
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