Effect of Recording Duration on Heart Rate Variability During taVNS

Starting soon · Not applicable · Has a placebo group

Conditions studied: Healthy Volunteers

In brief

This study aims to evaluate how different heart rate variability (HRV) recording durations reflect autonomic nervous system responses during transcutaneous auricular vagus nerve stimulation (taVNS) in healthy adults. In a randomized, sham-controlled crossover design, participants will attend two separate sessions and receive both active taVNS and sham stimulation in randomized order. During each session, a continuous 10-minute HRV recording will be obtained, and 1-minute, 5-minute, and 10-minute analysis windows will be compared. Blood pressure and pulse will also be measured before and after stimulation. The study will investigate whether shorter or longer HRV recording durations provide results comparable to the standard 5-minute recording and which duration most reliably detects autonomic changes during taVNS.

Key facts

Study ID

NCT07526415

Run by

Sinop University

People needed

40

Starts

2026-05-01

Expected to finish

2026-09-15

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers aged 18 to 40 years
• Able and willing to provide informed consent
• Able to tolerate active transcutaneous auricular vagus nerve stimulation and sham stimulation
• Able to comply with study instructions, including restrictions related to caffeine, nicotine, and heavy exercise before assessment
• No condition preventing heart rate variability, blood pressure, or pulse measurements

You may not qualify if…

• Diagnosed cardiovascular disease, arrhythmia, or pacemaker use
• History of neurologic disease that may affect autonomic nervous system function
• Regular use of medications that may affect heart rate variability or autonomic responses, including beta blockers, antiarrhythmics, or anticholinergic drugs
• Active ear infection, dermatologic lesion, or any ear condition that may interfere with stimulation
• Marked pain, discomfort, or intolerance during stimulation
• Acute infection, fever, or other acute health problem on the measurement day
• Heart rate variability data that cannot be evaluated because of excessive motion artifact

Where it is running

• Artvin Coruh University, Artvin Vocational School, Disabled Care and Rehabilitation Laboratory, Artvin, — Artvin, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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