Cerebral Oximetry, Pulmonary Artery Catheter Parameters and ECMO Flow in Patients Supported With Veno-arterial ECMO

Starting soon

Conditions studied: Mechanical Circulatory Support

In brief

for patients connected to VA ECMO due to cardiogenic shock, monitoring: 1. Cerebral Oximetry 2. ECMO Parameters ECMO blood flow (L/min) every 12 hours. Sweep gas flow Cannulation configuration 3. Pulmonary Artery Catheter Data and hemodynamics: Cardiac output / cardiac index, SvO₂, Central venous pressure (CVP). 4. other variables: P/F ratio, MAP, Heart rate, Arterial blood gases, hemoglobin, Lactate, Vasopressor / inotrope doses and Sedation score (RASS). 5. Echocardiography parameters: recorded every 12 hours. LV ejection fraction. LVOT VTi. LVED dimension. Aortic valve opening. 6. Follow-up data: * ECMO duration. * Need for oxygen therapy/mechanical ventilation. * ICU survival.

Key facts

Study ID

NCT07526181

Run by

Assiut University

People needed

30

Starts

2026-04-20

Expected to finish

2027-06-30

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Patients supported with veno-arterial ECMO.
• Presence of a pulmonary artery catheter.
• Expected ECMO support ≥ 24 hours.
• Patient with good echocardiographic window.

You may not qualify if…

• Pre-existing severe neurological injury (e.g. massive stroke, traumatic brain injury).
• Intracranial pathology affecting NIRS reliability.
• Facial or scalp conditions preventing NIRS probe placement.
• ECMO duration < 48 hours.
• Poor echocardiographic window.

Full record on ClinicalTrials.gov

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