Effect of Sciatic Nerve Mobilization on Lower Extremity Pain Perception

Enrolling by invitation · Not applicable

Conditions studied: Sciatic Nerve, Lower Extremity Pain

In brief

This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group. Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded. Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.

Key facts

Study ID

NCT07525895

Run by

Fenerbahce University

People needed

34

Starts

2026-03-20

Expected to finish

2026-12-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18 to 30 years
• Being a student at Fenerbahçe University
• No history of major trauma or surgery in the lower extremity within the last 6 months
• Voluntarily agreeing to participate in the study and signing the informed consent form

You may not qualify if…

• History of neurological disease
• History of lower extremity peripheral nerve injury
• Having undergone lower extremity surgery within the last 6 months
• Regular use of analgesic or muscle relaxant medications
• Pregnancy
• Presence of any systemic disease that may interfere with the assessment or intervention procedures

Where it is running

• Fenerbahçe University — Istanbul, Ataşehir, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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