Temporary Uterine Tourniquet Application Versus Local Myometrial Epinephrine Injection During Laparoscopic Myomectomy
Recruiting now · Not applicable
Conditions studied: Laparoscopic Myomectomy
In brief
While both local vasoconstrictors and tourniquet application are recognized methods for blood loss control, there is a paucity of head-to-head randomized controlled trials directly comparing these two distinct approaches in laparoscopic myomectomy. Existing data often compare these methods to no intervention or to other less common techniques. A direct comparison is essential to determine which method offers superior hemostasis with an acceptable safety profile in the laparoscopic setting. This study aims to address this gap in the literature.
Key facts
- Study ID
- NCT07525687
- Run by
- Minia University
- People needed
- 74
- Starts
- 2026-04-20
- Expected to finish
- 2027-01-20
- Last updated by the study team
- 2026-07-21
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female patients aged 18-45 years.
- Diagnosed with symptomatic uterine leiomyomas requiring laparoscopic myomectomy.
- Presence of at least one myoma with a diameter ≥3 cm and ≤10 cm.
- Patients with up to 3 myomas (to standardize surgical complexity).
- Preoperative hemoglobin level ≥10 g/dL.
- Ability to provide informed consent.
You may not qualify if…
- Patients with more than 3 myomas or any myoma larger than 10 cm.
- Patients with suspected uterine malignancy (e.g., leiomyosarcoma).
- Patients with known bleeding disorders or on anticoagulant therapy that cannot be safely discontinued.
- Patients with significant cardiovascular disease, uncontrolled hypertension, or arrhythmias (relative contraindications for epinephrine).
- Patients with active pelvic infection.
- Patients with previous extensive uterine surgery (e.g., multiple prior myomectomies or extensive uterine reconstruction) that may compromise uterine integrity.
- Patients undergoing concurrent major gynecological procedures that might significantly affect blood loss (e.g., hysterectomy, extensive adhesiolysis).
- Patients with known allergy to epinephrine.
- Patients unwilling or unable to comply with follow-up protocols.
Where it is running
- Minia advanced laparoscopy unit — Minya, Egypt (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.