A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: HIV Infections

In brief

VH4770359 (also known as GSK4770359) is an antiretroviral compound. This first-in-human study aims to evaluate the safety, tolerability, and pharmacokinetics (PK) of orally administered VH4770359 in healthy participants. The findings from this study will support the design of future clinical studies of VH4770359 in people living with HIV.

Key facts

Study ID

NCT07525544

Run by

ViiV Healthcare

People needed

214

Starts

2026-05-14

Expected to finish

2027-05-05

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 55 years old
• BMI 18.5-37.0 kg/m2
• Male participants must adhere to contraception requirements or abstinence, and female participants must not be pregnant/breastfeeding and be of non-childbearing potential.

You may not qualify if…

• Participants with significant medical history that could alter drug pharmacokinetics, pose a risk, or interfere with conduct.
• Has exclusionary psychiatric, hepatic, cardiovascular, gastrointestinal, respiratory, endocrine, neurological, hematological, or renal condition, or exclusionary malignancy.
• A positive test(s) for Hepatitis B surface antigen (HBsAg) and/or anti-HBc, hepatitis C antibodies, or human immunodeficiency virus (HIV).
• A history of or ongoing high-risk behaviors for HIV acquisition.
• Use of prohibited medications.
• Exclusionary allergies or sensitivities.
• Regular use of alcohol, drugs of abuse, tobacco, or nicotine products.
• Exclusionary prior or concurrent clinical study participation.

Where it is running

• GSK Investigational Site — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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