Nigella Sativa Oil for Eczematous Otitis Externa

Recruiting now · Not applicable

Conditions studied: Eczema/Atopic Dermatitis, Otitis Externa

In brief

Eczematous otitis externa is a common inflammatory condition of the external auditory canal characterized by itching, discomfort, discharge, and pain. Topical corticosteroids are widely used for treatment; however, alternative therapies with fewer side effects are of increasing interest. This study aims to compare the efficacy of Nigella sativa (black seed) oil and mometasone furoate ear drops in the treatment of eczematous otitis externa. Nigella sativa is a natural product with known anti-inflammatory and antimicrobial properties. In this randomized, controlled clinical trial, adult patients with eczematous otitis externa will be assigned to receive either Nigella sativa oil or mometasone furoate ear drops for 10 days. Clinical symptoms and inflammatory findings will be evaluated at baseline and after treatment. The objective of this study is to determine whether Nigella sativa oil is an effective and safe alternative to topical corticosteroid therapy.

Key facts

Study ID

NCT07525505

Run by

Bezmialem Vakif University

People needed

85

Starts

2026-01-12

Expected to finish

2026-07-01

Last updated by the study team

2026-04-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 years and older
• Clinical diagnosis of eczematous otitis externa confirmed by otoscopic examination
• Presence of at least one symptom related to the affected ear (itching, discomfort, otorrhea, or pain)
• Willingness to participate and ability to provide written informed consent

You may not qualify if…

• Known hypersensitivity or allergic reaction to Nigella sativa oil or mometasone furoate
• Use of topical or systemic corticosteroids or other ear medications within a defined period prior to enrollment
• Presence of acute otitis externa of infectious origin requiring antibiotic treatment
• History of ear surgery or structural abnormalities of the external auditory canal
• Severe systemic disease or condition that may interfere with study participation
• Pregnant or breastfeeding women

Where it is running

• Bezmialem Vakif University — Istanbul, Fatih, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.