Trial Phase: Syndemic Adapted Medly Uganda

Starting soon · Not applicable

Conditions studied: Mental Health

In brief

The purpose of this study is to evaluate the effectiveness of the Syndemic-Adapted Medly Uganda (SAMU) in improving mental health care among adults living with HIV and hypertension in Uganda. In sub-Saharan Africa (SSA), there is a high prevalence of depression and anxiety among people living with HIV (PLHIV) as well as alcohol use disorder (AUD). PLHIV who experience depression are less likely to link to HIV care, adhere to antiretroviral therapy, and achieve viral suppression. Building on research conducted to adapt Medly Uganda for mental health using a syndemic framework, this study aims to assess the effectiveness of SAMU on mental health screening and diagnosis. This will be accomplished through a two-arm trial in which 1. participants will be enrolled, screened, re-screened, and assessed for diagnosis and linkage to care for depression, anxiety and AUD and 2. evaluate the factors impacting sustained engagement in the SAMU program, through mixed methods.

Key facts

Study ID

NCT07525271

Run by

Yale University

People needed

1500

Starts

2026-07-01

Expected to finish

2028-06-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient at a participating HIV clinic site
• Currently living in Uganda with no intention of moving abroad in next 2 years
• Access to a mobile phone
• Basic reading skills in one or more of the offered languages (English, Luganda) as determined by the Research Assistant.

You may not qualify if…

• No access to a mobile phone
• Inability to provide informed consent based on assessment by the onsite Research Assistant or HCW
• Healthcare Workers/Caregivers Criteria:
• Age >=18 years
• Healthcare worker at participating site or caregiver for study participant at site
• Basic reading skills in one or more of the offered languages (English, Luganda) as determined by the Research Assistant

Where it is running

• Kawaala Hospital — Kampala, Uganda
• Naguru Hospital — Kampala, Uganda
• Nsambya Hospital — Kampala, Uganda

Full record on ClinicalTrials.gov

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