PREnatal Choline and Infant Outcomes Study

Recruiting now · Not applicable

Conditions studied: Nutrition During Pregnancy

In brief

Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB/GYNs were likely to recommend choline-rich foods to pregnant women. Nutrition education grounded in the Health Belief Model (HBM) has high efficacy among pregnant women; therefore, it is likely that HBM-driven choline education intervention will increase maternal choline levels. No studies have evaluated the influence of prenatal choline education intervention on maternal, placental, and neonatal outcomes. Our preliminary data suggest that increased choline intake corresponds with lower maternal body fat percentage (BF%), infant 1-month BF%, and MSC lipid accumulation, as well as increased placental efficiency. The central hypothesis is that choline education will increase maternal choline levels and improve placental function and infant health. We will test this hypothesis with three aims: to determine the influence of choline education intervention on maternal choline intake, placental efficiency, and infant health at the whole-body and cellular levels. The proposed study will be the first to provide a critical translational understanding of the influence of prenatal choline education intervention on maternal, placental, and child health.

Key facts

Study ID

NCT07525193

Run by

East Carolina University

People needed

102

Starts

2025-05-15

Expected to finish

2027-05-14

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy pregnant individual
• Singleton pregnancy
• 18-40 years of age
• Pre-pregnancy BMI ≥ 18.5

You may not qualify if…

• Any non-pregnancy-related illness or chronic condition that may impact fetal development (i.e., HIV, cancer, heart disease, pre-existing diabetes) or known fetal anomaly
• Food allergy to choline-rich foods (i.e., eggs)
• Multi fetal pregnancy
• >40 years of age

Where it is running

• East Carolina University — Greenville, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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