Antagonism of Neostigmine in Continuous Infusion of Mivacurium

Starting soon · Not applicable

Conditions studied: Neuromuscular Blocking Agents

In brief

In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism was explored.

Key facts

Study ID

NCT07524959

Run by

Beijing Tongren Hospital

People needed

120

Starts

2026-05-01

Expected to finish

2026-07-29

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 - 65 years old;
• American Society of Anesthesiologists (ASA) physical stastus classification system: I-II;
• Body mass index (BMI) 18.5 - 30 kg/m2
• Patients with normal cholinesterase levels before the operation

You may not qualify if…

• Refusal to participate in the study;
• ASA classification of grade III or above;
• Severe organ dysfunction, difficult airway or neurological muscle disorders;
• Taking drugs that affect neuromuscular monitoring or neuromuscular conduction function;
• Allergic to the test drug or having other contraindications;
• Pregnant and lactating women

Where it is running

• Beijing tongren Hospital, Capital Medical University — Beijing, Beijing Municipality, China

Full record on ClinicalTrials.gov

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