Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial
Starting soon · Phase 3
Conditions studied: Coronary Artery Disease, Subclinical Atherosclerotic Cardiovascular Disease
In brief
In patients with subclinical coronary artery disease, the ASCAD-P study aims to assess the feasibility of a larger phase 3 pragmatic randomized controlled trial comparing prescription versus no prescription of low-dose aspirin in routine clinical practice.
Key facts
- Study ID
- NCT07524335
- Run by
- Montreal Heart Institute
- People needed
- 48
- Starts
- 2026-05-01
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-05-12
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Documented coronary atherosclerosis, as defined by one of the following criteria:
- Coronary artery calcium (CAC) score > 0;
- Cardiac CT angiography (CCTA) / CoroScan: lesions <70% in the right coronary (RCA), left anterior descending (LAD), and circumflex (Cx) arteries or their branches, and <50% in the left main coronary artery;
- Coronary angiography: lesions <70% in the right coronary (RCA), left anterior descending (LAD), and circumflex (Cx) arteries or their branches, and <50% in the left main coronary artery; if performed, physiological coronary assessments (FFR, dPR, iFR, etc.) and intracoronary imaging (IVUS or OCT) must be negative for significant disease.
- Willing and able to provide informed consent and comply with study procedures
You may not qualify if…
- History of myocardial infarction (MI), coronary revascularization, stroke, transient ischemic attack (TIA), or peripheral arterial revascularization procedure;
- Current prescription or clear indication for aspirin, low-molecular-weight heparin (LMWH), direct oral anticoagulants, or any other antithrombotic medication;
- Clear contraindication to aspirin;
- History of significant bleeding within the past year;
- Severe illness with limited life expectancy (i.e., <5 years);
- Any condition that, in the investigator's judgment, would make participation unsafe for the patient.
Where it is running
- Montreal Heart Institute — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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