Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Polymorphonuclear Cells in the Middle Turbinate
Starting soon · Not applicable
Conditions studied: Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
In brief
This monocentric, interventional study (category RIPH2) aims to characterize the rheological properties of sinonasal secretions in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The primary objective is to determine differences in mucus viscosity between CRSwNP patients and a control group. By establishing a correlation between local rheology and systemic Type 2 inflammation biomarkers, the study seeks to develop a non-invasive, rapid "point-of-care" tool to refine patient phenotyping and improve the personalization of biological treatments.
Key facts
- Study ID
- NCT07524127
- Run by
- University Hospital, Montpellier
- People needed
- 60
- Starts
- 2026-08-01
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-04-13
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient requiring sinonasal surgery
- For patients in the CRSwNP group:
- Presence of nasal polyposis defined according to EPOS 2020 recommendations:
- Clinical examination revealing, for at least 12 weeks prior to inclusion, 2 or more of the following symptoms:
- Nasal congestion
- Rhinorrhea (anterior/posterior)
- Or a Facial pain/pressure
- Or a Reduced or lost sense of smell AND visible polyps in both nasal cavities on endoscopic examination of the middle meatus (regardless of size).
You may not qualify if…
- Inability to provide a sinonasal secretion sample by blowing
- Conditions causing secondary nasal polyposis (e.g., cystic fibrosis, ciliary dyskinesia, immune disorders, allergic fungal sinusitis)
- Illiteracy
- Lack of consent
- Legal protection status (guardianship, curatorship, etc.)
- No social security coverage
- Persons deprived of liberty by judicial or administrative decision
- Participation in another study with an ongoing exclusion period
Where it is running
- University hospital Montpellier — Montpellier, France
Full record on ClinicalTrials.gov
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