Multi-Omics-Based Novel Thrombosis and Bleeding Markers and Risk Model for CHD

Recruiting now

Conditions studied: Thrombosis, Bleeding, Coronary Artery Disease (CAD)

In brief

Patients with coronary heart disease who take dual antiplatelet therapy face two serious risks: thrombosis and major bleeding. This study aims to develop better ways to predict these risks and guide personalized treatment. The investigators will use a large, long-term follow-up study of Chinese patients with coronary heart disease. This research plans to discover new biomarkers related to clot and bleeding risk. The study will combine information from proteins, metabolites, sugars attached to proteins, genes, and medical images. Using machine learning methods, the investigators will identify the most important markers and test them in the patient group of this study. The investigators will then build new risk prediction models that include these new markers together with traditional risk scores (such as GRACE, PARIS, and Precise-DAPT). This study will check whether these new models are better than existing ones at predicting who will develop clots or bleeding and at helping doctors decide on the best treatment for each patient. The new aspects of this research are: (1) using advanced multi-omics technology to find novel markers specifically for Chinese patients; (2) combining clinical, biological, and imaging data to improve prediction accuracy; and (3) using machine learning to create more precise risk models. The goal is to provide doctors with a more accurate tool to assess each patient's risk of clots and bleeding. This will help them choose the safest and most effective antiplatelet treatment, reduce serious complications, and improve patient care.

Key facts

Study ID: NCT07523880
Run by: Xueyan Zhao
People needed: 12154
Starts: 2025-08-01
Expected to finish: 2029-07-01
Last updated by the study team: 2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥ 18 years.
Hospitalized due to symptoms or objective evidence of coronary heart disease and planned for long-term antithrombotic therapy.
Diagnosis of acute coronary syndrome or stable coronary heart disease undergoing percutaneous coronary intervention (PCI), with clinical stability meeting discharge criteria after treatment.
For patients from the existing cohort: minimum 2 years of follow-up with complete clinical data and blood specimens available; approval for use of these data and specimens has been obtained, with a waiver of re-consent.
For newly enrolled patients: voluntary written informed consent provided by the patient or legal representative, agreement to provide blood samples, and acceptance of follow-up procedures.

You may not qualify if…

For patients from the existing cohort:
Severe missing or erroneous baseline or clinical data that cannot be corrected by source verification.
No available blood specimen, or specimen that does not meet testing requirements.
For newly enrolled patients:
Presence of serious comorbid conditions with life expectancy ≤ 6 months.
Conditions that significantly affect study compliance or the ability to complete follow-up.
Contraindications to blood sampling.

Where it is running

Fuwai Central China Cardiovascular Hospital — Zhengzhou, Henan, China (enrolling)
General Hospital of Northern Theater Command of Chinese People's Liberation Army — Shenyang, Liaoning, China (enrolling)
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.